Products intended only for professional use. Can be injected by a certified medical professional.

The Next Re-Generation

AnGelHA

The World's First Biostimulating Dual Co-Matrix Gelatin & Hyaluronic Acid dermal fillers.

An Aesthetic Paradigm Shift.

Immediate Volume. True Regeneration.

About AnGelHA

AnGelHA is an innovative biostimulating dermal filler line combining Hyaluronic Acid and Gelatin in a unique co-matrix structure. This synergistic formulation enhances fibroblast activity, promoting collagen and elastin production.

By combining the volumizing effect of Hyaluronic Acid with the regenerative properties of Gelatin, AnGelHA delivers immediate results while supporting long-term tissue regeneration and skin rejuvenation.

WHAT MAKES ANGELHA DIFFERENT

RGD Motifs: Bioactive only in Gelatin,
not in Collagen

A unique Hyaluronic Acid–Gelatin structure that combines immediate volumization with biological stimulation of fibroblasts.

REGENERATIVE MECHANISM

Promotes collagen and elastin production, supporting progressive improvement in skin quality over time.

PRECISION & SAFETY

Monophasic, non-particulate gel designed for controlled placement, including delicate areas.

FULL CONTROL

Fully reversible, allowing safe and predictable treatment outcomes.

VERSATILE APPLICATION

A single platform adaptable across multiple indications — from superficial refinement to structural

FULL-FACE
TREATMENT PLATFORM

Designed for full-face treatment, AnGelHA addresses all facial indications - from delicate areas to structural contouring - without the need to combine multiple technologies.

THE SCIENCE OF REGENERATION

A dual-action mechanism combining structural support with biological stimulation — enabling true skin regeneration.

Gelatin — Biological Activation

Derived from denatured collagen, gelatin exposes RGD motifs that promote fibroblast adhesion and recruitment, initiating the regenerative process.

Hyaluronic Acid — Functional Support

Provides hydration and a supportive extracellular environment, enhancing fibroblast movement, proliferation, and cellular activity.

Co-Matrix — Regenerative Architecture

A unique interpenetrating network that mimics the extracellular matrix, enabling fibroblast anchoring and stimulating the production of collagen, elastin, and glycosaminoglycans.

This synergistic interaction supports progressive tissue remodeling and long-term skin rejuvenation.

THE ANGELHA RANGE

One regenerative platform. Multiple treatment goals.

AnGelHA 1
Delicate Precision

Fine lines and sensitive areas

Tear trough

Glabella

Perioral

Crow’s feet

AnGelHA 2
Versatile Correction

Mid-face rejuvenation and contouring

Chin

Cheekbones

Marionette

Marionette

Temples

Jawline

AnGelHA 3
Structural Definition

High support for contouring and lift

Jawline

Cheekbones

Lips
Regenerative Lip Enhancement

Volume, structure, and tissue renewal

Estima
Skin Quality & Regeneration

Subtle rejuvenation without added volume

Chin

Lips

Cheeks

Perioral

Glabella

clinical results

The results shown below are 3 weeks after the second treatment. A notable improvement can be seen in the appearance of the wrinkles, their depth, and the skin texture, without a significant increase in volume.

Clinical Trial (ESTIMA)

Overview

  • Objective: Assess safety & efficacy in improving skin texture & fine lines
  • Treatment Protocol: 2-3 sessions, spaced 2-4 weeks apart. Maintenance session at 6 months.
  • Treatment Areas: Cheeks, perioral lines, lips, chin, glabella
  • Injection Techniques: micro-injections / cannula sheeting
  • Injection Volume: The mean injected volume at 12 months was 0.85 ▒ 0.25 mL
  • Follow up: 2W, 1M, 6M, 12M
  • Study Population: 24 subjects

Effectiveness & Long-Lasting Result

  • 61% of physicians rated “very muchimproved” at 12months
  • 100% improvement rating by physicians at 12months
  • 84% of physicianand 72% of patients reported improvementafter 1 treatment
  • 0% Adverse events (other than slightand common treatment reactions)

DESIGNED FOR SAFETY
AND CONTROL

A refined formulation designed to ensure safety, precision, and confidence in every treatment.
    • Fully reversible — complete control with hyaluronidase or collagenase
    • Monophasic, non-particulate gel — smooth, uniform integration
    • Safe for delicate areas — including lips and periocular regions
    • Predictable performance — consistent and controlled clinical outcomes

    FROM AGING TO REGENERATION

    With age, collagen and elastin decline — leading to loss of structure and elasticity.

    YOUNG SKIN

    MATURE SKIN

    01

    PRECISION DELIVERY

    AnGelHA is precisely placed within the dermis to initiate regeneration at the source.

    From activation to regeneration — AnGelHA restores skin from within.

    02

    BIOLOGICAL ACTIVATION

    Gelatin exposes RGD motifs that promote fibroblast adhesion and recruitment - initiating the regenerative process.

    From activation to regeneration — AnGelHA restores skin from within.

    03

    COLLAGEN & ELASTIN PRODUCTION

    Activated fibroblasts produce new collagen, elastin, and glycosaminoglycans - restoring

    From activation to regeneration — AnGelHA restores skin from within.

    THE POWER OF GELATIN

    Gelatin is not just a carrier — it is the bioactive engine
    that drives true skin regeneration

    Bioactive RGD Motifs

    Exposed in gelatin, RGD sequences promote fibroblast adhesion and recruitment — initiating regeneration.

    Enhanced Cellular Activation

    Supports fibroblast proliferation and activity, amplifying the regenerative response beyond hyaluronic acid alone.

    Superior Biostimulation

    The combination of HA and gelatin delivers stronger biological stimulation compared to HA-based fillers.

    Optimized Tissue Integration

    Promotes cell anchoring and migration within the dermis, supporting natural tissue remodeling.

    REGENERATIVE TREATMENT PROTOCOL (AnGelHA ESTIMA)

    Designed to stimulate progressive collagen and elastin production

    3 sessions
    2–4 weeks apart
    2 syringes per session

    :Treatment areas
    Cheeks, perioral lines, lips, chin, glabella